| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2E1 |
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| Ligand | BDBM50088490 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1487043 (CHEMBL3531869) |
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| Ki | >30000±n/a nM |
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| Citation |  Foti, RS; Pearson, JT; Wong, SL; Zalikowski, JA; Boudreaux, MD; Prokop, SP; Davis, JA; Banfield, C; Emery, MG; Rock, DA; Wahlstrom, JL; Wienkers, LC; Amore, BM Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors. Drug Metab Dispos40:2239-49 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2E1 |
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| Name: | Cytochrome P450 2E1 |
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| Synonyms: | CP2E1_HUMAN | CYP2E | CYP2E1 | Cytochrome P450 2E1 (CYP2E1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56860.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05181 |
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| Residue: | 493 |
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| Sequence: | MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA
EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF
ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK
FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC
IPPRYKLCVIPRS
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| BDBM50088490 |
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| n/a |
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| Name | BDBM50088490 |
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| Synonyms: | CHEMBL3526979 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H35Cl2FN2O12S |
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| Mol. Mass. | 785.617 |
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| SMILES | CC(C)(C)NC(=O)c1ccc(Oc2cc(F)c(CC(=O)O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)cc2Cl)c(NS(=O)(=O)c2ccc(cc2Cl)C2CC2)c1 |r| |
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| Structure | 
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