| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-glucuronosyltransferase 1A1 |
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| Ligand | BDBM25351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1486475 (CHEMBL3531465) |
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| IC50 | 170000±n/a nM |
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| Citation |  Zhou, J; Tracy, TS; Remmel, RP Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos39:322-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-glucuronosyltransferase 1A1 |
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| Name: | UDP-glucuronosyltransferase 1A1 |
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| Synonyms: | Bilirubin-specific UDPGT isozyme 1 | GNT1 | UD11_HUMAN | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1 | hUG-BR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59604.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22309 |
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| Residue: | 533 |
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| Sequence: | MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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| BDBM25351 |
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| n/a |
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| Name | BDBM25351 |
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| Synonyms: | N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide | Raltegravir |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21FN6O5 |
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| Mol. Mass. | 444.4163 |
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| SMILES | Cc1nnc(o1)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C |
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| Structure | 
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