| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
|---|
| Ligand | BDBM50090092 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1497537 (CHEMBL3582669) |
|---|
| IC50 | 9.0±n/a nM |
|---|
| Citation |  René, O; Fauber, BP; Boenig, Gde L; Burton, B; Eidenschenk, C; Everett, C; Gobbi, A; Hymowitz, SG; Johnson, AR; Kiefer, JR; Liimatta, M; Lockey, P; Norman, M; Ouyang, W; Wallweber, HA; Wong, H Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action. ACS Med Chem Lett6:276-81 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor ROR-gamma |
|---|
| Name: | Nuclear receptor ROR-gamma |
|---|
| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 58218.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51449 |
|---|
| Residue: | 518 |
|---|
| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
|
|
|
|---|
| BDBM50090092 |
|---|
| n/a |
|---|
| Name | BDBM50090092 |
|---|
| Synonyms: | CHEMBL3581539 | US9216988, 85 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H29ClFN3O3S |
|---|
| Mol. Mass. | 494.022 |
|---|
| SMILES | CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccccc2Cl)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
