| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-alpha |
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| Ligand | BDBM50092605 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1500938 (CHEMBL3586834) |
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| IC50 | 6200±n/a nM |
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| Citation |  Toyama, H; Nakamura, M; Hashimoto, Y; Fujii, S Design and synthesis of novel ROR inverse agonists with a dibenzosilole scaffold as a hydrophobic core structure. Bioorg Med Chem23:2982-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-alpha |
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| Name: | Nuclear receptor ROR-alpha |
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| Synonyms: | NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58976.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_101591 |
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| Residue: | 523 |
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| Sequence: | MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVT
KKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRT
SRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAE
PLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIK
PEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITW
QTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGS
LEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEI
ALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRAL
CGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
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| BDBM50092605 |
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| n/a |
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| Name | BDBM50092605 |
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| Synonyms: | CHEMBL3586247 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26F6OSi |
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| Mol. Mass. | 460.5279 |
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| SMILES | CCCC[Si]1(CCCC)c2ccccc2-c2cc(ccc12)C(O)(C(F)(F)F)C(F)(F)F |
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| Structure | 
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