| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM50018011 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1503366 (CHEMBL3590869) |
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| IC50 | 1000±n/a nM |
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| Citation |  Lucas-Hourani, M; Munier-Lehmann, H; El Mazouni, F; Malmquist, NA; Harpon, J; Coutant, EP; Guillou, S; Helynck, O; Noel, A; Scherf, A; Phillips, MA; Tangy, F; Vidalain, PO; Janin, YL Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH). J Med Chem58:5579-98 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM50018011 |
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| n/a |
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| Name | BDBM50018011 |
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| Synonyms: | Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9F3N2O2 |
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| Mol. Mass. | 270.2073 |
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| SMILES | C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |
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| Structure | 
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