Reaction Details |
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Target | Nitric oxide synthase, endothelial |
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Ligand | BDBM50226527 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1503719 (CHEMBL3592390) |
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IC50 | 350000±n/a nM |
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Citation | Maccallini, C; Montagnani, M; Paciotti, R; Ammazzalorso, A; De Filippis, B; Di Matteo, M; Di Silvestre, S; Fantacuzzi, M; Giampietro, L; Potenza, MA; Re, N; Pandolfi, A; Amoroso, R Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies. ACS Med Chem Lett6:635-40 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nitric oxide synthase, endothelial |
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Name: | Nitric oxide synthase, endothelial |
Synonyms: | Constitutive NOS | Endothelial NOS | Endothelial nitric oxide synthase | Endothelial nitric-oxide synthase (eNOS) | NOS type III | NOS3 | NOS3_BOVIN | Nitric oxide synthase, endothelial (eNOS) | Nitric-oxide synthase, endothelial | cNOS |
Type: | Enzyme |
Mol. Mass.: | 133292.26 |
Organism: | Bos taurus (bovine) |
Description: | Recombinant eNOS overexpressed in E. coli was used in enzyme assays. |
Residue: | 1205 |
Sequence: | MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPT
LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRCCLGSLVLPRKLQTRPSPGPP
PAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR
GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE
APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM
STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV
DHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD
PWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA
AAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT
ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG
GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR
RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVA
VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI
APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS
REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME
LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP
DTPGP
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BDBM50226527 |
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n/a |
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Name | BDBM50226527 |
Synonyms: | CHEMBL107251 | N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE | N-(3-(aminomethyl)benzyl)acetimidamide | N-(3-Aminomethyl-benzyl)-acetamidine | N-(3-aminomethyl)benzylacetimidamide | N-[3-(aminomethyl)benzyl]ethanimidamide | N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide | [N-(3-aminomethyl)benzylactamidine] |
Type | Small organic molecule |
Emp. Form. | C10H15N3 |
Mol. Mass. | 177.2462 |
SMILES | CC(N)=NCc1cccc(CN)c1 |w:3.3| |
Structure |
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