Reaction Details |
| Report a problem with these data |
Target | Protein arginine N-methyltransferase 6 |
---|
Ligand | BDBM50095438 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1504108 (CHEMBL3591482) |
---|
IC50 | 3.0±n/a nM |
---|
Citation | Mitchell, LH; Drew, AE; Ribich, SA; Rioux, N; Swinger, KK; Jacques, SL; Lingaraj, T; Boriack-Sjodin, PA; Waters, NJ; Wigle, TJ; Moradei, O; Jin, L; Riera, T; Porter-Scott, M; Moyer, MP; Smith, JJ; Chesworth, R; Copeland, RA Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett6:655-9 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Protein arginine N-methyltransferase 6 |
---|
Name: | Protein arginine N-methyltransferase 6 |
Synonyms: | ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6) |
Type: | Protein |
Mol. Mass.: | 41928.48 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 375 |
Sequence: | MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEM
IADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQA
REVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKE
GGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQG
LSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGE
SEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYK
VGDQEEKTKDFAMED
|
|
|
BDBM50095438 |
---|
n/a |
---|
Name | BDBM50095438 |
Synonyms: | CHEMBL3589042 |
Type | Small organic molecule |
Emp. Form. | C23H29N5O2 |
Mol. Mass. | 407.5087 |
SMILES | CNCCN(C)Cc1c[nH]nc1-c1ccc(Oc2cccc(c2)C(=O)N(C)C)cc1 |
Structure |
|