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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Potassium voltage-gated channel subfamily H member 2 | ||
| Ligand | BDBM50095759 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1504608 (CHEMBL3591513) | ||
| Ki | 48±n/a nM | ||
| Citation |  Yu, Z; van Veldhoven, JP; Louvel, J; 't Hart, IM; Rook, MB; van der Heyden, MA; Heitman, LH; IJzerman, AP Structure-Affinity Relationships (SARs) and Structure-Kinetics Relationships (SKRs) of Kv11.1 Blockers. J Med Chem58:5916-29 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Potassium voltage-gated channel subfamily H member 2 | |||
| Name: | Potassium voltage-gated channel subfamily H member 2 | ||
| Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 126672.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q12809 | ||
| Residue: | 1159 | ||
| Sequence: |
| ||
| BDBM50095759 | |||
| n/a | |||
| Name | BDBM50095759 | ||
| Synonyms: | CHEMBL3590458 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25ClNO | ||
| Mol. Mass. | 342.882 | ||
| SMILES | C[N+]1(CCc2ccccc2)CCC(CC1)C(=O)c1ccc(Cl)cc1 |(-7.72,-.15,;-6.67,-.78,;-6.62,-2.3,;-5.29,-3.07,;-5.28,-4.61,;-3.95,-5.38,;-3.94,-6.92,;-5.28,-7.69,;-6.61,-6.92,;-6.61,-5.38,;-6.67,.76,;-5.34,1.53,;-4,.77,;-4,-.77,;-5.33,-1.55,;-2.67,1.54,;-2.67,2.77,;-1.33,.77,;,1.54,;1.33,.77,;1.33,-.77,;2.4,-1.39,;,-1.54,;-1.33,-.77,)| | ||
| Structure | 
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