Reaction Details |
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Target | von Hippel-Lindau disease tumor suppressor |
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Ligand | BDBM50446138 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1459715 (CHEMBL3370433) |
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Kd | 5300±n/a nM |
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Citation | Galdeano, C; Gadd, MS; Soares, P; Scaffidi, S; Van Molle, I; Birced, I; Hewitt, S; Dias, DM; Ciulli, A Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. J Med Chem57:8657-63 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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von Hippel-Lindau disease tumor suppressor |
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Name: | von Hippel-Lindau disease tumor suppressor |
Synonyms: | Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL |
Type: | Protein |
Mol. Mass.: | 24136.87 |
Organism: | Homo sapiens (Human) |
Description: | P40337 |
Residue: | 213 |
Sequence: | MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPR
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFR
DAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI
VRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
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BDBM50446138 |
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n/a |
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Name | BDBM50446138 |
Synonyms: | CHEMBL3108881 |
Type | Small organic molecule |
Emp. Form. | C21H22N4O5 |
Mol. Mass. | 410.4232 |
SMILES | Cc1cc(CC(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2cnco2)on1 |r| |
Structure |
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