| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 3 |
|---|
| Ligand | BDBM50102494 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1441431 (CHEMBL3373386) |
|---|
| IC50 | 17±n/a nM |
|---|
| Citation |  Yang, W; Li, L; Ji, X; Wu, X; Su, M; Sheng, L; Zang, Y; Li, J; Liu, H Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors. Bioorg Med Chem22:6146-55 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 3 |
|---|
| Name: | Histone deacetylase 3 |
|---|
| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48829.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15379 |
|---|
| Residue: | 428 |
|---|
| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
|
|
|
|---|
| BDBM50102494 |
|---|
| n/a |
|---|
| Name | BDBM50102494 |
|---|
| Synonyms: | CHEMBL3339015 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21F2N5O3S |
|---|
| Mol. Mass. | 449.474 |
|---|
| SMILES | ONC(=O)CCCCCCC(=O)Nc1cc2c(Nc3ccc(F)cc3F)ncnc2s1 |
|---|
| Structure | 
|
|---|
Search and Browse
