| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-8 |
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| Ligand | BDBM50099831 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1446797 (CHEMBL3371271) |
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| IC50 | 2.1±n/a nM |
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| Citation |  de Bruin, G; Huber, EM; Xin, BT; van Rooden, EJ; Al-Ayed, K; Kim, KB; Kisselev, AF; Driessen, C; van der Stelt, M; van der Marel, GA; Groll, M; Overkleeft, HS Structure-based design of฿1i or฿5i specific inhibitors of human immunoproteasomes. J Med Chem57:6197-209 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-8 |
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| Name: | Proteasome subunit beta type-8 |
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| Synonyms: | 26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30357.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1446797 |
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| Residue: | 276 |
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| Sequence: | MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGD
GERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGC
AADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKG
PGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDS
YSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
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| BDBM50099831 |
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| n/a |
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| Name | BDBM50099831 |
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| Synonyms: | CHEMBL3319586 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H43N5O6 |
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| Mol. Mass. | 665.7779 |
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| SMILES | C[C@@H](NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)[C@@]1(C)CO1 |r| |
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| Structure | 
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