| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-9 |
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| Ligand | BDBM50099950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1446800 (CHEMBL3371274) |
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| IC50 | 66±n/a nM |
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| Citation |  de Bruin, G; Huber, EM; Xin, BT; van Rooden, EJ; Al-Ayed, K; Kim, KB; Kisselev, AF; Driessen, C; van der Stelt, M; van der Marel, GA; Groll, M; Overkleeft, HS Structure-based design of฿1i or฿5i specific inhibitors of human immunoproteasomes. J Med Chem57:6197-209 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-9 |
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| Name: | Proteasome subunit beta type-9 |
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| Synonyms: | LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 23256.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_106197 |
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| Residue: | 219 |
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| Sequence: | MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
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| BDBM50099950 |
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| n/a |
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| Name | BDBM50099950 |
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| Synonyms: | CHEMBL3319601 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H39N7O6 |
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| Mol. Mass. | 569.6526 |
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| SMILES | CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)CN=[N+]=[N-])C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r| |
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| Structure | 
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