| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proteasome subunit beta type-9 |
|---|
| Ligand | BDBM50099954 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1446800 (CHEMBL3371274) |
|---|
| IC50 | 104±n/a nM |
|---|
| Citation |  de Bruin, G; Huber, EM; Xin, BT; van Rooden, EJ; Al-Ayed, K; Kim, KB; Kisselev, AF; Driessen, C; van der Stelt, M; van der Marel, GA; Groll, M; Overkleeft, HS Structure-based design of฿1i or฿5i specific inhibitors of human immunoproteasomes. J Med Chem57:6197-209 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proteasome subunit beta type-9 |
|---|
| Name: | Proteasome subunit beta type-9 |
|---|
| Synonyms: | LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 23256.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_106197 |
|---|
| Residue: | 219 |
|---|
| Sequence: | MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
|
|
|
|---|
| BDBM50099954 |
|---|
| n/a |
|---|
| Name | BDBM50099954 |
|---|
| Synonyms: | CHEMBL3319605 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H48N2O5Si |
|---|
| Mol. Mass. | 484.7445 |
|---|
| SMILES | CCCCCCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(CO[Si](C)(C)C(C)(C)C)CO1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
