| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-10 |
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| Ligand | BDBM50099664 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1446802 (CHEMBL3371276) |
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| IC50 | >10000±n/a nM |
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| Citation |  de Bruin, G; Huber, EM; Xin, BT; van Rooden, EJ; Al-Ayed, K; Kim, KB; Kisselev, AF; Driessen, C; van der Stelt, M; van der Marel, GA; Groll, M; Overkleeft, HS Structure-based design of฿1i or฿5i specific inhibitors of human immunoproteasomes. J Med Chem57:6197-209 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-10 |
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| Name: | Proteasome subunit beta type-10 |
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| Synonyms: | LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28940.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_106197 |
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| Residue: | 273 |
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| Sequence: | MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT
NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR
ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR
FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR
YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
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| BDBM50099664 |
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| n/a |
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| Name | BDBM50099664 |
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| Synonyms: | CHEMBL3319483 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H44N4O5 |
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| Mol. Mass. | 624.7691 |
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| SMILES | C[C@@H](NC(=O)C1=C(C)c2ccccc2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC1CCCCC1)C(=O)[C@@]1(C)CO1 |r,c:5| |
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| Structure | 
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