| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
|---|
| Ligand | BDBM50192858 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1448596 |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Horbert, R; Pinchuk, B; Johannes, E; Schlosser, J; Schmidt, D; Cappel, D; Totzke, F; Schächtele, C; Peifer, C Optimization of potent DFG-in inhibitors of platelet derived growth factor receptorß (PDGF-Rß) guided by water thermodynamics. J Med Chem58:170-82 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PLK1 |
|---|
| Name: | Serine/threonine-protein kinase PLK1 |
|---|
| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 68277.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P53350 |
|---|
| Residue: | 603 |
|---|
| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
|
|
|
|---|
| BDBM50192858 |
|---|
| n/a |
|---|
| Name | BDBM50192858 |
|---|
| Synonyms: | CHEMBL3358966 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H19N3O4 |
|---|
| Mol. Mass. | 377.3933 |
|---|
| SMILES | COc1cc(cc(OC)c1OC)-c1nc(c[nH]c1=O)-c1c[nH]c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
