| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fructose-1,6-bisphosphatase 1 |
|---|
| Ligand | BDBM50101430 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1460519 (CHEMBL3395429) |
|---|
| IC50 | 1290±n/a nM |
|---|
| Citation |  Bie, J; Liu, S; Li, Z; Mu, Y; Xu, B; Shen, Z Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Eur J Med Chem90:394-405 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fructose-1,6-bisphosphatase 1 |
|---|
| Name: | Fructose-1,6-bisphosphatase 1 |
|---|
| Synonyms: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36843.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Liver FBPase (P09467) |
|---|
| Residue: | 338 |
|---|
| Sequence: | MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
|
|
|
|---|
| BDBM50101430 |
|---|
| n/a |
|---|
| Name | BDBM50101430 |
|---|
| Synonyms: | CHEMBL3393936 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H9BrN2O6 |
|---|
| Mol. Mass. | 357.114 |
|---|
| SMILES | OC(=O)CCc1c([nH]c2c(cc(Br)cc12)[N+]([O-])=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
