| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM50102099 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1447268 (CHEMBL3378611) |
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| EC50 | 4960±n/a nM |
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| Citation |  Ma, J; Chen, D; Lu, K; Wang, L; Han, X; Zhao, Y; Gong, P Design, synthesis, and structure-activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents. Eur J Med Chem86:257-69 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM50102099 |
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| n/a |
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| Name | BDBM50102099 |
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| Synonyms: | CHEMBL3330094 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28ClN5O3S |
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| Mol. Mass. | 538.061 |
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| SMILES | CCN(CC)Cc1ccc2nc(NC(=O)N\N=C\c3ccc(OCc4ccc(Cl)cc4)cc3O)sc2c1 |
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| Structure | 
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