Reaction Details |
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Target | Bifunctional protein GlmU |
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Ligand | BDBM50102670 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1443091 (CHEMBL3380797) |
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IC50 | 18000±n/a nM |
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Citation | Doig, P; Boriack-Sjodin, PA; Dumas, J; Hu, J; Itoh, K; Johnson, K; Kazmirski, S; Kinoshita, T; Kuroda, S; Sato, TO; Sugimoto, K; Tohyama, K; Aoi, H; Wakamatsu, K; Wang, H Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping. Bioorg Med Chem22:6256-69 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional protein GlmU |
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Name: | Bifunctional protein GlmU |
Synonyms: | Bifunctional protein (GlmU) | GLMU_ECOLI | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU | yieA |
Type: | Enzyme |
Mol. Mass.: | 49189.50 |
Organism: | Escherichia coli |
Description: | P0ACC7 |
Residue: | 456 |
Sequence: | MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGD
LLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDA
KPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADM
KRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQ
SEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKN
SVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSK
AGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGAT
IAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
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BDBM50102670 |
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n/a |
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Name | BDBM50102670 |
Synonyms: | CHEMBL3343046 |
Type | Small organic molecule |
Emp. Form. | C21H18N2O4 |
Mol. Mass. | 362.3786 |
SMILES | COc1cc(ccc1O)C(=O)Nc1ccc(NC(=O)c2ccccc2)cc1 |
Structure |
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