| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Matrix metalloproteinase-14 |
|---|
| Ligand | BDBM50025159 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1431426 (CHEMBL3389269) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Nara, H; Sato, K; Naito, T; Mototani, H; Oki, H; Yamamoto, Y; Kuno, H; Santou, T; Kanzaki, N; Terauchi, J; Uchikawa, O; Kori, M Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach. J Med Chem57:8886-902 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Matrix metalloproteinase-14 |
|---|
| Name: | Matrix metalloproteinase-14 |
|---|
| Synonyms: | MMP-14 | MMP-X1 | MMP14 | MMP14_HUMAN | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | Matrix metalloproteinase 14 | Matrix metalloproteinase-14 | Matrix metalloproteinase-14 (MMP14) | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 65900.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P50281 |
|---|
| Residue: | 582 |
|---|
| Sequence: | MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS
LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ
HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF
FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE
LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT
SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF
WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF
WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA
AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
|
|
|
|---|
| BDBM50025159 |
|---|
| n/a |
|---|
| Name | BDBM50025159 |
|---|
| Synonyms: | CHEMBL3337869 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15N3O3 |
|---|
| Mol. Mass. | 309.3193 |
|---|
| SMILES | COc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
