| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
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| Ligand | BDBM50106333 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1506587 (CHEMBL3598340) |
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| IC50 | 40800±n/a nM |
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| Citation |  Srinivas, V; Mohan, CD; Baburajeev, CP; Rangappa, S; Jagadish, S; Fuchs, JE; Sukhorukov, AY; Chandra, na; Mason, DJ; Sharath Kumar, KS; Madegowda, M; Bender, A; Basappa, na; Rangappa, KS Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2. Bioorg Med Chem Lett25:2931-6 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 1 |
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| Name: | Prostaglandin G/H synthase 1 |
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| Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 68692.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23219 |
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| Residue: | 599 |
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| Sequence: | MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
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| BDBM50106333 |
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| n/a |
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| Name | BDBM50106333 |
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| Synonyms: | CHEMBL3596289 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23ClN2O |
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| Mol. Mass. | 402.916 |
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| SMILES | CC1(C)CC(C(Cn2c3ccccc3c3ccccc23)=NO1)c1ccc(Cl)cc1 |c:22| |
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| Structure | 
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