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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Phosphatidylinositol 4-kinase alpha | ||
| Ligand | BDBM50107257 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1508840 (CHEMBL3603389) | ||
| IC50 | 1.000000±n/a nM | ||
| Citation |  Raubo, P; Andrews, DM; McKelvie, JC; Robb, GR; Smith, JM; Swarbrick, ME; Waring, MJ Discovery of potent, selective small molecule inhibitors ofa-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIa). Bioorg Med Chem Lett25:3189-93 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Phosphatidylinositol 4-kinase alpha | |||
| Name: | Phosphatidylinositol 4-kinase alpha | ||
| Synonyms: | PI4-kinase alpha | PI4-kinase alpha subunit | PI4K-alpha | PI4KA | PI4KA/PI4KAP2 | PI4KA_HUMAN | PIK4 | PIK4 | PIK4CA | Phosphatidylinositol 4-kinase alpha | Phosphatidylinositol 4-kinase alpha (PI4KA) | PtdIns-4-kinase alpha | ||
| Type: | Protein | ||
| Mol. Mass.: | 231326.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P42356 | ||
| Residue: | 2102 | ||
| Sequence: |
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| BDBM50107257 | |||
| n/a | |||
| Name | BDBM50107257 | ||
| Synonyms: | CHEMBL3600785 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27N3O3S | ||
| Mol. Mass. | 437.554 | ||
| SMILES | OC(=O)[C@H]1CC[C@H](CNc2nc3ccc(cc3s2)-c2ccn(CC3CC3)c(=O)c2)CC1 |r,wU:6.6,wD:3.2,(11.72,2.53,;11.11,1.45,;11.74,.39,;9.57,1.44,;8.78,2.76,;7.24,2.75,;6.49,1.4,;4.95,1.38,;4.2,.04,;2.66,.02,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;.3,.77,;1.76,1.24,;-3.71,1.53,;-5.05,.76,;-6.38,1.53,;-6.38,3.07,;-7.72,3.83,;-9.05,3.06,;-10.51,3.1,;-9.73,1.77,;-5.05,3.84,;-5.05,5.07,;-3.72,3.07,;7.28,.08,;8.82,.1,)| | ||
| Structure | 
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