Reaction Details |
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Target | Interleukin-1 receptor-associated kinase 4 |
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Ligand | BDBM50108086 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1509409 (CHEMBL3603417) |
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IC50 | 4.0±n/a nM |
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Citation | Seganish, WM; McElroy, WT; Herr, RJ; Brumfield, S; Greenlee, WJ; Harding, J; Komanduri, V; Matasi, J; Prakash, KC; Tulshian, D; Yang, J; Yet, L; Devito, K; Fossetta, J; Garlisi, CG; Lundell, D; Niu, X; Sondey, C Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4. Bioorg Med Chem Lett25:3203-7 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor-associated kinase 4 |
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Name: | Interleukin-1 receptor-associated kinase 4 |
Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
Type: | Protein |
Mol. Mass.: | 51519.08 |
Organism: | Homo sapiens (Human) |
Description: | Q9NWZ3 |
Residue: | 460 |
Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM50108086 |
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n/a |
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Name | BDBM50108086 |
Synonyms: | CHEMBL3601072 | US9598440, 66 |
Type | Small organic molecule |
Emp. Form. | C24H27N7O3S |
Mol. Mass. | 493.581 |
SMILES | CN(C)c1ccc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc1 |r| |
Structure |
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