| Reaction Details |
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 | Report a problem with these data |
| Target | Thyrotropin-releasing hormone receptor |
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| Ligand | BDBM50072394 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1508580 (CHEMBL3602663) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Meena, CL; Thakur, A; Nandekar, PP; Sangamwar, AT; Sharma, SS; Jain, R Synthesis of CNS active thyrotropin-releasing hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice. Bioorg Med Chem23:5641-53 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyrotropin-releasing hormone receptor |
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| Name: | Thyrotropin-releasing hormone receptor |
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| Synonyms: | TRH-R2 | Thyrotropin-releasing hormone receptor 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27545.04 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109850 |
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| Residue: | 251 |
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| Sequence: | MDGPSNVSLVHGDTTLGLPEYKVVSVLLVLLVCTVGIVGNAMVVLVVLTSRDMHTPTNCY
LVSLALADLIVLLAAGLPNVSDSLVGHWIYGHAGCLGITYFQYLGINVSSCSILAFTVER
YIAICHPMRAQTVCTVARARRIIAGIWGVTSLYCLLWFFLVDLNVRDNQRLECGYKVSRG
LYLPIYLLDFAVFFIAPLLGTLVLYGFIGRILFQSPLSQEAWQKERQSHGQSEGTPGNCS
RSKSSMSSRKQ
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| BDBM50072394 |
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| n/a |
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| Name | BDBM50072394 |
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| Synonyms: | 1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyrrolylcarboxamido)propanoyl]tetrahydro-1H-2-pyrrolecarboxamide | A-38579 | ABBOTT-38579 | PROTIRELIN |
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| Type | Small organic molecule |
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| Emp. Form. | C16H22N6O4 |
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| Mol. Mass. | 362.3837 |
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| SMILES | NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r| |
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| Structure | 
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