| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM50110169 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1510175 (CHEMBL3606546) |
|---|
| IC50 | 3320±n/a nM |
|---|
| Citation |  Rudolph, DA; Alcazar, J; Ameriks, MK; Anton, AB; Ao, H; Bonaventure, P; Carruthers, NI; Chrovian, CC; De Angelis, M; Lord, B; Rech, JC; Wang, Q; Bhattacharya, A; Andres, JI; Letavic, MA Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists. Bioorg Med Chem Lett25:3157-63 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68403.50 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q64663 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
|
|
|
|---|
| BDBM50110169 |
|---|
| n/a |
|---|
| Name | BDBM50110169 |
|---|
| Synonyms: | CHEMBL2218113 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H12Cl2N6O |
|---|
| Mol. Mass. | 375.212 |
|---|
| SMILES | Clc1cccc(C(=O)N2CCn3c(C2)nnc3-c2cnccn2)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
