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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50112145 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1512870 (CHEMBL3611792) | ||
| IC50 | 56±n/a nM | ||
| Citation |  Hong, SP; Nam, KY; Shin, YJ; Kim, KW; Ahn, SK Discovery of 11ß-hydroxysteroid dehydrogenase type 1 inhibitor. Bioorg Med Chem Lett25:3501-6 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32369.70 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | P50172 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM50112145 | |||
| n/a | |||
| Name | BDBM50112145 | ||
| Synonyms: | CHEMBL3609873 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H37N3O4S | ||
| Mol. Mass. | 475.644 | ||
| SMILES | CC(C)(C)c1ccc(cc1)S(=O)(=O)NC(C)(C)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O |r,wD:20.20,TLB:24:25:29:28.22.23,24:23:29:20.25.26,20:21:28:25.24.26,THB:19:20:29:28.22.23,20:25:28:29.22.21,(-14.57,1.58,;-14.39,.36,;-15.36,-.4,;-15.54,.82,;-12.96,-.21,;-12.74,-1.74,;-11.31,-2.31,;-10.1,-1.35,;-10.32,.17,;-11.75,.74,;-8.67,-1.93,;-7.53,-2.38,;-8.5,-3.15,;-7.46,-.97,;-6.03,-1.55,;-7,-2.31,;-5.85,-2.77,;-4.82,-.59,;-4.99,.63,;-3.39,-1.17,;-2.19,-.22,;-.95,.32,;-1,2.05,;.12,3.07,;-1.2,2.69,;-1.2,1.02,;.34,.44,;1.56,1.02,;1.56,2.59,;.56,-.22,;3.07,1.15,;3.78,.15,;3.59,2.27,)| | ||
| Structure | 
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