| Reaction Details |
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 | Report a problem with these data |
| Target | Amiloride-sensitive sodium channel subunit alpha |
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| Ligand | BDBM50112172 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1512947 (CHEMBL3609986) |
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| IC50 | 13±n/a nM |
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| Citation |  Blass, B Novel Pyrazine Amide Compounds. ACS Med Chem Lett6:729-31 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amiloride-sensitive sodium channel subunit alpha |
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| Name: | Amiloride-sensitive sodium channel subunit alpha |
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| Synonyms: | Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNNA_MOUSE | Scnn1a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78903.70 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109863 |
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| Residue: | 699 |
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| Sequence: | MLDHTRAPELNLDLDLDVSNSPKGSMKGNNFKEQDLCPPLPMQGLGKGDKREEQALGPEP
SEPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTF
GMMYWQFALLFEEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITE
QTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDN
NPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEE
ALGSFIFTCRFNQAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLR
TEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGD
CTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSW
GYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYT
INNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELI
FDLLVITLIMLLHRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGT
TPPLALTAPPPAYATLGPSASPLDSAVPGSSACAPAMAL
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| BDBM50112172 |
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| n/a |
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| Name | BDBM50112172 |
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| Synonyms: | CHEMBL3608427 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H54Cl2N8O7 |
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| Mol. Mass. | 805.791 |
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| SMILES | [Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCCO)cc2)(CCCc2ccc(OCC(=O)NCCCO)cc2)C1 |r| |
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| Structure | 
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