| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 5 |
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| Ligand | BDBM50112903 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1508708 (CHEMBL3602971) |
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| IC50 | 6.7±n/a nM |
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| Citation |  Cai, M; Marelli, UK; Bao, J; Beck, JG; Opperer, F; Rechenmacher, F; McLeod, KR; Zingsheim, MR; Doedens, L; Kessler, H; Hruby, VJ Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. J Med Chem58:6359-67 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 5 |
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| Name: | Melanocortin receptor 5 |
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| Synonyms: | MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36612.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33032 |
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| Residue: | 325 |
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| Sequence: | MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
EMRKTFKEIICCRGFRIACSFPRRD
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| BDBM50112903 |
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| n/a |
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| Name | BDBM50112903 |
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| Synonyms: | CHEMBL3600914 |
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| Type | Small organic molecule |
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| Emp. Form. | C57H77N15O9 |
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| Mol. Mass. | 1116.3164 |
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| SMILES | CCCC[C@@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r| |
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| Structure | 
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