| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
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| Ligand | BDBM50113654 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1510717 (CHEMBL3606319) |
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| IC50 | 1.8±n/a nM |
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| Citation |  Bagdanoff, JT; Jain, R; Han, W; Poon, D; Lee, PS; Bellamacina, C; Lindvall, M Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase. Bioorg Med Chem Lett25:3626-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 |
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| Name: | Mitogen-activated protein kinase 1 |
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| Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
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| Type: | Ser/Thr Protein Kinase |
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| Mol. Mass.: | 41392.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28482 |
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| Residue: | 360 |
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| Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM50113654 |
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| n/a |
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| Name | BDBM50113654 |
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| Synonyms: | CHEMBL3604854 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20FN5O |
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| Mol. Mass. | 401.4362 |
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| SMILES | Fc1ccc(Cn2ccc(cc2=O)N2CCc3[nH]nc(c3C2)-c2ccncc2)cc1 |
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| Structure | 
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