| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 1 |
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| Ligand | BDBM50115617 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1513932 (CHEMBL3611614) |
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| IC50 | 1.02±n/a nM |
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| Citation |  Murray, JK; Qian, YX; Liu, B; Elliott, R; Aral, J; Park, C; Zhang, X; Stenkilsson, M; Salyers, K; Rose, M; Li, H; Yu, S; Andrews, KL; Colombero, A; Werner, J; Gaida, K; Sickmier, EA; Miu, P; Itano, A; McGivern, J; Gegg, CV; Sullivan, JK; Miranda, LP Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3. J Med Chem58:6784-802 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 1 |
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| Name: | Potassium voltage-gated channel subfamily A member 1 |
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| Synonyms: | KCNA1 | KCNA1_HUMAN | Potassium (voltage dependent) | Potassium voltage-gated channel subfamily A member 1 | Voltage-gated potassium channel | Voltage-gated potassium channel subfamily A member 1/beta-1 | Voltage-gated potassium channel subunit Kv1.1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56451.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Potassium (voltage dependent) 0 0::Q09470 |
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| Residue: | 495 |
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| Sequence: | MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN
TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY
ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS
IVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRF
FACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVF
RIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIP
DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE
GEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTT
ANQNCVNKSKLLTDV
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| BDBM50115617 |
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| n/a |
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| Name | BDBM50115617 |
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| Synonyms: | CHEMBL3609257 |
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| Type | Small organic molecule |
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| Emp. Form. | C179H280N54O47S7 |
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| Mol. Mass. | 4164.927 |
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| SMILES | [H][C@@]12CCCN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@H](CC(O)=O)NC(=O)[C@@]([H])(NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@]1([H])CSSC[C@]3([H])NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CSSC[C@]([H])(NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cccc5ccccc45)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC |r| |
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| Structure | 
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