| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein phosphatase 1D |
|---|
| Ligand | BDBM50118477 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1515092 (CHEMBL3614136) |
|---|
| IC50 | 110±n/a nM |
|---|
| Citation |  Ogasawara, S; Kiyota, Y; Chuman, Y; Kowata, A; Yoshimura, F; Tanino, K; Kamada, R; Sakaguchi, K Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation. Bioorg Med Chem23:6246-9 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein phosphatase 1D |
|---|
| Name: | Protein phosphatase 1D |
|---|
| Synonyms: | PP2C-delta | PPM1D | PPM1D_HUMAN | Protein phosphatase 2C isoform delta | Protein phosphatase magnesium-dependent 1 delta | WIP1 | p53-induced protein phosphatase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66695.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1515094 |
|---|
| Residue: | 605 |
|---|
| Sequence: | MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPG
GEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHL
WGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVII
RGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSG
VNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHT
LDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQ
RMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVK
SLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAK
ALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEE
SNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRK
TVCVC
|
|
|
|---|
| BDBM50118477 |
|---|
| n/a |
|---|
| Name | BDBM50118477 |
|---|
| Synonyms: | CHEMBL3613748 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H48O4Si2 |
|---|
| Mol. Mass. | 456.8065 |
|---|
| SMILES | [H][C@]12C[C@@H](C[C@@](C)(C(O)=O)[C@]1([H])CCC[C@H]2O[Si](CC)(CC)CC)O[Si](C)(C)C(C)(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
