| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-14 |
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| Ligand | BDBM50119282 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1518241 (CHEMBL3620108) |
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| IC50 | 23±n/a nM |
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| Citation |  Nuti, E; Cantelmo, AR; Gallo, C; Bruno, A; Bassani, B; Camodeca, C; Tuccinardi, T; Vera, L; Orlandini, E; Nencetti, S; Stura, EA; Martinelli, A; Dive, V; Albini, A; Rossello, A N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity. J Med Chem58:7224-40 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-14 |
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| Name: | Matrix metalloproteinase-14 |
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| Synonyms: | MMP-14 | MMP-X1 | MMP14 | MMP14_HUMAN | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | Matrix metalloproteinase 14 | Matrix metalloproteinase-14 | Matrix metalloproteinase-14 (MMP14) | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase |
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| Type: | Protein |
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| Mol. Mass.: | 65900.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50281 |
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| Residue: | 582 |
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| Sequence: | MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS
LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ
HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF
FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE
LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT
SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF
WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF
WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA
AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
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| BDBM50119282 |
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| n/a |
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| Name | BDBM50119282 |
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| Synonyms: | CHEMBL3617404 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29N3O7S |
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| Mol. Mass. | 479.547 |
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| SMILES | COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N(OC(C)C)[C@H](CCNC(C)=O)C(=O)NO |r| |
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| Structure | 
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