| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM203492 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520136 (CHEMBL3625600) |
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| IC50 | 27±n/a nM |
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| Citation |  Seganish, WM; Fischmann, TO; Sherborne, B; Matasi, J; Lavey, B; McElroy, WT; Tulshian, D; Tata, J; Sondey, C; Garlisi, CG; Devito, K; Fossetta, J; Lundell, D; Niu, X Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors. ACS Med Chem Lett6:942-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM203492 |
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| n/a |
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| Name | BDBM203492 |
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| Synonyms: | US9221809, 29 | US9221809, 65 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27N5O4S |
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| Mol. Mass. | 505.589 |
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| SMILES | OC[C@H]1C[C@@H](Nc2nc([nH]c(=O)c2-c2nc3ccccc3s2)N2CCc3ccccc3C2)[C@H](O)[C@@H]1O |r| |
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| Structure | 
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