| Reaction Details |
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 | Report a problem with these data |
| Target | Aromatase |
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| Ligand | BDBM50009605 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520468 (CHEMBL3624597) |
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| IC50 | 4600±n/a nM |
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| Citation |  Ahmad, I; Shagufta, na Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer. Eur J Med Chem102:375-86 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aromatase |
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| Name: | Aromatase |
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| Synonyms: | Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58418.09 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_51211 |
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| Residue: | 508 |
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| Sequence: | MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLI
SHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKR
GLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTD
NSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWL
YRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCI
LEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFI
NESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEK
NVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLH
LDEDSPIVEIIFRHIFNTPFLQCLYISL
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| BDBM50009605 |
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| n/a |
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| Name | BDBM50009605 |
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| Synonyms: | 2-(pyridin-4-ylmethylene)-3,4-dihydronaphthalen-1(2H)-one | 2-Pyridin-4-ylmethylene-3,4-dihydro-2H-naphthalen-1-one | 2-[1-Pyridin-4-yl-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one | CHEMBL90585 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13NO |
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| Mol. Mass. | 235.2805 |
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| SMILES | O=C1\C(CCc2ccccc12)=C\c1ccncc1 |
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| Structure | 
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