| Reaction Details |
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 | Report a problem with these data |
| Target | LIM domain kinase 2 |
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| Ligand | BDBM50124355 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520364 (CHEMBL3624102) |
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| IC50 | 3.0±n/a nM |
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| Citation |  Charles, MD; Brookfield, JL; Ekwuru, TC; Stockley, M; Dunn, J; Riddick, M; Hammonds, T; Trivier, E; Greenland, G; Wong, AC; Cheasty, A; Boyd, S; Crighton, D; Olson, MF Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties. J Med Chem58:8309-13 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| LIM domain kinase 2 |
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| Name: | LIM domain kinase 2 |
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| Synonyms: | LIMK2 | LIMK2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 72238.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1514398 |
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| Residue: | 638 |
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| Sequence: | MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
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| BDBM50124355 |
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| n/a |
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| Name | BDBM50124355 |
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| Synonyms: | CHEMBL3623442 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18ClN3OS |
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| Mol. Mass. | 371.884 |
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| SMILES | CC(C)C(=O)Nc1ncc(s1)-c1ccncc1-c1ccc(C)cc1Cl |
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| Structure | 
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