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Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cystine/glutamate transporter | ||
| Ligand | BDBM50126160 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1523603 (CHEMBL3631402) | ||
| IC50 | 4.0±n/a nM | ||
| Citation |  Larraufie, MH; Yang, WS; Jiang, E; Thomas, AG; Slusher, BS; Stockwell, BR Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility. Bioorg Med Chem Lett25:4787-92 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cystine/glutamate transporter | |||
| Name: | Cystine/glutamate transporter | ||
| Synonyms: | SLC7A11 | XCT_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 55437.48 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_772170 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| BDBM50126160 | |||
| n/a | |||
| Name | BDBM50126160 | ||
| Synonyms: | CHEMBL3629669 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C44H49ClN6O6 | ||
| Mol. Mass. | 793.349 | ||
| SMILES | COc1ccc(CN2CCN(CC(=O)c3ccc(OC(C)C)c(c3)-n3c(CN4CCN(CC4)C(=O)COc4ccc(Cl)cc4)nc4ccccc4c3=O)CC2)cc1 |(13.56,-8.32,;14.63,-7.72,;14.64,-6.18,;15.98,-5.41,;15.99,-3.87,;14.66,-3.1,;14.66,-1.55,;13.33,-.78,;13.34,.76,;12,1.53,;10.67,.77,;9.33,1.54,;8,.76,;8,-.47,;6.66,1.53,;6.67,3.07,;5.33,3.85,;4,3.08,;2.67,3.85,;2.67,5.4,;1.61,6.02,;3.74,6.01,;4,1.54,;5.33,.77,;2.66,.77,;2.66,-.77,;3.99,-1.54,;3.99,-3.08,;5.32,-3.86,;5.32,-5.4,;3.98,-6.16,;2.65,-5.39,;2.66,-3.85,;3.97,-7.7,;5.04,-8.32,;2.64,-8.47,;2.63,-10.01,;1.29,-10.77,;1.28,-12.31,;-.06,-13.07,;-1.39,-12.29,;-2.46,-12.9,;-1.38,-10.75,;-.04,-9.99,;1.33,-1.54,;,-.77,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;1.33,2.77,;10.67,-.77,;12,-1.55,;13.32,-3.86,;13.31,-5.4,)| | ||
| Structure | 
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