| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50128343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1523722 (CHEMBL3631861) |
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| IC50 | 4100±n/a nM |
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| Citation |  Kang, JH; Ting, Z; Moon, MR; Sim, JS; Lee, JM; Doh, KE; Hong, S; Cui, M; Choi, S; Chang, HW; Park Choo, HY; Yim, M 5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression. Bioorg Med Chem23:7069-78 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | 5-LO | 5-lipoxygenase | Alox5 | Arachidonate 5-lipoxygenase | LOX5_MOUSE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 77961.27 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_675639 |
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| Residue: | 674 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGAVDSYDVTVDE
ELGEIYLVKIEKRKYWLHDDWYLKYITLKTPHGDYIEFPCYRWITGEGEIVLRDGRAKLA
RDDQIHILKQHRRKELEARQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNG
CNPVLIKRCTALPPKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDP
CTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGESNPIFLPTDSKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLICEYG
LFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDSTEDIPFYFYRDDGLLVWE
AIQSFTMEVVSIYYENDQVVEEDQELQDFVKDVYVYGMRGKKASGFPKSIKSREKLSEYL
TVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCW
HLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPY
YYLSPDRIPNSVAI
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| BDBM50128343 |
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| n/a |
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| Name | BDBM50128343 |
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| Synonyms: | CHEMBL3629176 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N5O4 |
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| Mol. Mass. | 459.4971 |
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| SMILES | N\C(=N/O)c1ccc(OCCCCC(=O)Nc2ccc3oc(Nc4ccccc4)nc3c2)cc1 |
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| Structure | 
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