Reaction Details |
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Target | DNA gyrase subunit B |
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Ligand | BDBM50135114 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1542254 (CHEMBL3745476) |
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IC50 | <8±n/a nM |
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Citation | Zhang, J; Yang, Q; Romero, JA; Cross, J; Wang, B; Poutsiaka, KM; Epie, F; Bevan, D; Wu, Y; Moy, T; Daniel, A; Chamberlain, B; Carter, N; Shotwell, J; Arya, A; Kumar, V; Silverman, J; Nguyen, K; Metcalf, CA; Ryan, D; Lippa, B; Dolle, RE Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors. ACS Med Chem Lett6:1080-5 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA gyrase subunit B |
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Name: | DNA gyrase subunit B |
Synonyms: | DNA gyrase | DNA gyrase subunit B (DNA gyraseB) | DNA gyrase subunit B (gyrB) | GYRB_STAAU | gyrB |
Type: | Enzyme Subunit |
Mol. Mass.: | 72530.91 |
Organism: | Staphylococcus aureus |
Description: | n/a |
Residue: | 644 |
Sequence: | MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
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BDBM50135114 |
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n/a |
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Name | BDBM50135114 |
Synonyms: | CHEMBL3742072 |
Type | Small organic molecule |
Emp. Form. | C18H16N5Na2O5PS |
Mol. Mass. | 491.368 |
SMILES | [Na+].[Na+].CCCOc1nccc2c(n[nH]c12)-c1cnc(s1)-c1ccc(COP([O-])([O-])=O)nc1 |
Structure |
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