Reaction Details |
| Report a problem with these data |
Target | Mitogen-activated protein kinase 8 |
---|
Ligand | BDBM15997 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1544313 (CHEMBL3751430) |
---|
IC50 | 28±n/a nM |
---|
Citation | Simon-Szabó, L; Kokas, M; Greff, Z; Boros, S; Bánhegyi, P; Zsákai, L; Szántai-Kis, C; Vantus, T; Mandl, J; Bánhegyi, G; Vályi-Nagy, I; Orfi, L; Ullrich, A; Csala, M; Kéri, G Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes. Bioorg Med Chem Lett26:424-8 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Mitogen-activated protein kinase 8 |
---|
Name: | Mitogen-activated protein kinase 8 |
Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
Type: | Enzyme |
Mol. Mass.: | 48297.57 |
Organism: | Homo sapiens (Human) |
Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
Residue: | 427 |
Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
|
|
|
BDBM15997 |
---|
n/a |
---|
Name | BDBM15997 |
Synonyms: | 2-({2-[(3-fluorophenyl)amino]pyrimidin-4-yl}amino)benzoic acid | 4-anilinopyrimidine 8f |
Type | Small organic molecule |
Emp. Form. | C17H13FN4O2 |
Mol. Mass. | 324.3091 |
SMILES | OC(=O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 |
Structure |
|