| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C iota type |
|---|
| Ligand | BDBM50135286 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1543403 (CHEMBL3750007) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Reddy, MV; Akula, B; Jatiani, S; Vasquez-Del Carpio, R; Billa, VK; Mallireddigari, MR; Cosenza, SC; Venkata Subbaiah, DR; Bharathi, EV; Pallela, VR; Ramkumar, P; Jain, R; Aggarwal, AK; Reddy, EP Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). Bioorg Med Chem24:521-44 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C iota type |
|---|
| Name: | Protein kinase C iota type |
|---|
| Synonyms: | Atypical protein kinase C-lambda/iota | DXS1179E | KPCI_HUMAN | PRKC-lambda/iota | PRKCI | Protein kinase C (PKC) | Protein kinase C iota | Protein kinase C iota (PKCι) | Protein kinase C iota type | Protein kinase C iota type/zeta type | aPKC-lambda/iota | nPKC-iota |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68251.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41743 |
|---|
| Residue: | 596 |
|---|
| Sequence: | MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF
DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE
DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR
ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ
TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA
EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI
APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR
IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK
PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
|
|
|
|---|
| BDBM50135286 |
|---|
| n/a |
|---|
| Name | BDBM50135286 |
|---|
| Synonyms: | CHEMBL3745885 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H15F2N5O3S |
|---|
| Mol. Mass. | 467.448 |
|---|
| SMILES | Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
