| Reaction Details |
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 | Report a problem with these data |
| Target | Elastase |
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| Ligand | BDBM50299053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1550090 (CHEMBL3756036) |
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| IC50 | 29000±n/a nM |
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| Citation |  Sjøli, S; Nuti, E; Camodeca, C; Bilto, I; Rossello, A; Winberg, JO; Sylte, I; Adekoya, OA Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors. Eur J Med Chem108:141-53 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Elastase |
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| Name: | Elastase |
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| Synonyms: | ELAS_PSEAE | Pseudolysin | lasB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53687.94 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | ChEMBL_619859 |
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| Residue: | 498 |
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| Sequence: | MKKVSTLDLLFVAIMGVSPAAFAADLIDVSKLPSKAAQGAPGPVTLQAAVGAGGADELKA
IRSTTLPNGKQVTRYEQFHNGVRVVGEAITEVKGPGKSVAAQRSGHFVANIAADLPGSTT
AAVSAEQVLAQAKSLKAQGRKTENDKVELVIRLGENNIAQLVYNVSYLIPGEGLSRPHFV
IDAKTGEVLDQWEGLAHAEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMN
SSTDDSKTTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKLYMK
VHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQNSGLIYRGQSGGMN
EAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYMDQPSRDGRSIDNASQYYNGIDVH
HSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSAQNRNYSA
ADVTRAFSTVGVTCPSAL
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| BDBM50299053 |
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| n/a |
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| Name | BDBM50299053 |
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| Synonyms: | CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulfonyl)phenyl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15NO5S |
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| Mol. Mass. | 321.348 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO |
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| Structure | 
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