| Reaction Details |
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 | Report a problem with these data |
| Target | D(3) dopamine receptor |
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| Ligand | BDBM50139861 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1554000 (CHEMBL3768207) |
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| Ki | 126±n/a nM |
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| Citation |  Micheli, F; Cremonesi, S; Semeraro, T; Tarsi, L; Tomelleri, S; Cavanni, P; Oliosi, B; Perdonà, E; Sava, A; Zonzini, L; Feriani, A; Braggio, S; Heidbreder, C Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists. Bioorg Med Chem Lett26:1329-32 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(3) dopamine receptor |
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| Name: | D(3) dopamine receptor |
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| Synonyms: | DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3 |
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| Type: | Protein |
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| Mol. Mass.: | 49540.58 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P19020 |
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| Residue: | 446 |
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| Sequence: | MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC
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| BDBM50139861 |
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| n/a |
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| Name | BDBM50139861 |
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| Synonyms: | CHEMBL3764557 | US10577361, E7 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24F3N5O2S |
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| Mol. Mass. | 467.508 |
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| SMILES | Cc1ncoc1-c1nnc(SCCCN2CCOC(C2)c2ccc(cc2)C(F)(F)F)n1C |
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| Structure | 
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