| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
|---|
| Ligand | BDBM50143817 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1551188 (CHEMBL3761636) |
|---|
| IC50 | 7.0±n/a nM |
|---|
| Citation |  Nakajima, K; April, M; Brewer, JT; Daniels, T; Forster, CJ; Gilmore, TA; Jain, M; Kanter, A; Kwak, Y; Li, J; McQuire, L; Serrano-Wu, MH; Streeper, R; Szklennik, P; Thompson, J; Wang, B Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors. Bioorg Med Chem Lett26:1245-8 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol O-acyltransferase 1 |
|---|
| Name: | Diacylglycerol O-acyltransferase 1 |
|---|
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55297.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75907 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
|
|
|
|---|
| BDBM50143817 |
|---|
| n/a |
|---|
| Name | BDBM50143817 |
|---|
| Synonyms: | CHEMBL3758618 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H48N2O6 |
|---|
| Mol. Mass. | 544.7226 |
|---|
| SMILES | CC(C)C[C@H](OC(=O)C(C)(C)C)C(=O)NC1(CCCC1)C(=O)N[C@@H](CCc1ccccc1)C(=O)OC(C)(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
