Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50334349 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1551387 (CHEMBL3762508) |
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Ki | 5.7±n/a nM |
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Citation | Lomelino, CL; Mahon, BP; McKenna, R; Carta, F; Supuran, CT Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111. Bioorg Med Chem24:976-81 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50334349 |
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n/a |
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Name | BDBM50334349 |
Synonyms: | 4-(3-(3-nitrophenyl)ureido)benzenesulfonamide | 4-{[(3'-Nitrophenyl)carbamoyl]amino}benzenesulfonamide | 4-{[(3-nitrophenyl)carbamoyl]amino}benzenesulfonamide | CA IX inhibitor, (C)1 | CHEMBL1614844 |
Type | Small organic molecule |
Emp. Form. | C13H12N4O5S |
Mol. Mass. | 336.323 |
SMILES | NS(=O)(=O)c1ccc(NC(=O)Nc2cccc(c2)[N+]([O-])=O)cc1 |
Structure |
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