| Reaction Details |
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 | Report a problem with these data |
| Target | Inhibitor of nuclear factor kappa-B kinase subunit beta |
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| Ligand | BDBM50146937 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1553193 (CHEMBL3767151) |
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| IC50 | 3000±n/a nM |
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| Citation |  Kim, D; Kim, YG; Seo, JH; Shin, KJ Identification and characterization of potent, selective and metabolically stable IKKß inhibitor. Bioorg Med Chem Lett26:1120-3 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inhibitor of nuclear factor kappa-B kinase subunit beta |
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| Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
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| Synonyms: | IKKB_MOUSE | Ikbkb | Ikkb |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86687.79 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_835035 |
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| Residue: | 757 |
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| Sequence: | MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREG
AVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCF
RALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLV
LLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLK
AKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLE
SALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD
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| BDBM50146937 |
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| n/a |
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| Name | BDBM50146937 |
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| Synonyms: | CHEMBL3764369 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H30ClN3O3S2 |
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| Mol. Mass. | 580.161 |
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| SMILES | CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(Cl)cc4)cc3)C2=O)CC1 |
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| Structure | 
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