| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol lipase-beta |
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| Ligand | BDBM50147615 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1553507 (CHEMBL3768874) |
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| IC50 | 40±n/a nM |
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| Citation |  Chupak, LS; Zheng, X; Hu, S; Huang, Y; Ding, M; Lewis, MA; Westphal, RS; Blat, Y; McClure, A; Gentles, RG Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase. Bioorg Med Chem24:1455-68 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol lipase-beta |
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| Name: | Diacylglycerol lipase-beta |
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| Synonyms: | DAGLB | DGLB_HUMAN | Sn1-specific diacylglycerol lipase beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73731.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_557688 |
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| Residue: | 672 |
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| Sequence: | MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLI
VLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVA
DGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQ
LLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLA
LLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPL
TGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLV
ALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI
NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQ
EYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNP
NNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQ
EEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVS
CPAQGVSSVDVA
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| BDBM50147615 |
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| n/a |
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| Name | BDBM50147615 |
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| Synonyms: | CHEMBL3764876 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15Cl2F2NO5S |
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| Mol. Mass. | 502.315 |
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| SMILES | OC(=O)CN(c1cccc(c1)-c1cccc(Cl)c1Cl)S(=O)(=O)c1ccc(OC(F)F)cc1 |
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| Structure | 
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