| Reaction Details |
|---|
 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Ligand | BDBM50427452 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1553555 (CHEMBL3769087) |
|---|
| IC50 | <10000±n/a nM |
|---|
| Citation |  Veerman, J; van den Bergh, T; Orrling, KM; Jansen, C; Cos, P; Maes, L; Chatelain, E; Ioset, JR; Edink, EE; Tenor, H; Seebeck, T; de Esch, I; Leurs, R; Sterk, GJ Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals. Bioorg Med Chem24:1573-81 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68488.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O76083 |
|---|
| Residue: | 593 |
|---|
| Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
|
|
|
|---|
| BDBM50427452 |
|---|
| n/a |
|---|
| Name | BDBM50427452 |
|---|
| Synonyms: | CHEMBL2326941 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H40N6O4 |
|---|
| Mol. Mass. | 584.7085 |
|---|
| SMILES | COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12 |r,c:43,t:28| |
|---|
| Structure | 
|
|---|
Search and Browse
