| Reaction Details |
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 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1 |
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| Ligand | BDBM50148750 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1557115 (CHEMBL3773067) |
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| IC50 | 4.6±n/a nM |
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| Citation |  Huang, W; Ojo, KK; Zhang, Z; Rivas, K; Vidadala, RS; Scheele, S; DeRocher, AE; Choi, R; Hulverson, MA; Barrett, LK; Bruzual, I; Siddaramaiah, LK; Kerchner, KM; Kurnick, MD; Freiberg, GM; Kempf, D; Hol, WG; Merritt, EA; Neckermann, G; de Hostos, EL; Isoherranen, N; Maly, DJ; Parsons, M; Doggett, JS; Van Voorhis, WC; Fan, E SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. ACS Med Chem Lett6:1184-1189 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calmodulin-domain protein kinase 1 |
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| Name: | Calmodulin-domain protein kinase 1 |
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| Synonyms: | Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57248.42 |
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| Organism: | Toxoplasma gondii |
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| Description: | n/a |
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| Residue: | 507 |
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| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
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| BDBM50148750 |
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| n/a |
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| Name | BDBM50148750 |
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| Synonyms: | CHEMBL3770299 | US9518026, Example 71 | US9956214, Compound 1643 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N5O2 |
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| Mol. Mass. | 365.4289 |
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| SMILES | CC(C)(C)n1nc(c(C(N)=O)c1N)-c1ccc2nc(OC3CC3)ccc2c1 |
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| Structure | 
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