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TargetProto-oncogene tyrosine-protein kinase Src
LigandBDBM50148632
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1557117 (CHEMBL3773069)
IC50>30000±n/a nM
Citation Huang, WOjo, KKZhang, ZRivas, KVidadala, RSScheele, SDeRocher, AEChoi, RHulverson, MABarrett, LKBruzual, ISiddaramaiah, LKKerchner, KMKurnick, MDFreiberg, GMKempf, DHol, WGMerritt, EANeckermann, Gde Hostos, ELIsoherranen, NMaly, DJParsons, MDoggett, JSVan Voorhis, WCFan, E SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. ACS Med Chem Lett6:1184-1189 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proto-oncogene tyrosine-protein kinase Src
Name:Proto-oncogene tyrosine-protein kinase Src
Synonyms:Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:Protein
Mol. Mass.:59838.60
Organism:Homo sapiens (Human)
Description:P12931
Residue:536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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BDBM50148632
n/a
NameBDBM50148632
Synonyms:CHEMBL3770409 | US9518026, Example 40 | US9956214, Compound 1572
TypeSmall organic molecule
Emp. Form.C18H21N5O2
Mol. Mass.339.3916
SMILESCCOc1ccc2cc(cnc2c1)-c1nn(C(C)C)c(N)c1C(N)=O
Structure
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