| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
|---|
| Ligand | BDBM50149947 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1558444 (CHEMBL3773320) |
|---|
| IC50 | 2.9±n/a nM |
|---|
| Citation |  Zhang, H; Tong, R; Bai, L; Shi, J; Ouyang, L Emerging targets and new small molecule therapies in Parkinson's disease treatment. Bioorg Med Chem24:1419-30 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent serotonin transporter |
|---|
| Name: | Sodium-dependent serotonin transporter |
|---|
| Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 70168.43 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P31652 |
|---|
| Residue: | 630 |
|---|
| Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
|
|
|
|---|
| BDBM50149947 |
|---|
| n/a |
|---|
| Name | BDBM50149947 |
|---|
| Synonyms: | CHEMBL3770126 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21NO4 |
|---|
| Mol. Mass. | 351.3957 |
|---|
| SMILES | CN1C2CCC1CC(C2)Oc1ccc2cc(-c3ccoc3)c(=O)oc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
