| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 2 |
|---|
| Ligand | BDBM50150754 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1561959 (CHEMBL3778795) |
|---|
| IC50 | 1600±n/a nM |
|---|
| Citation |  Raux, B; Voitovich, Y; Derviaux, C; Lugari, A; Rebuffet, E; Milhas, S; Priet, S; Roux, T; Trinquet, E; Guillemot, JC; Knapp, S; Brunel, JM; Fedorov, AY; Collette, Y; Roche, P; Betzi, S; Combes, S; Morelli, X Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J Med Chem59:1634-41 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 2 |
|---|
| Name: | Bromodomain-containing protein 2 |
|---|
| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 88085.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25440 |
|---|
| Residue: | 801 |
|---|
| Sequence: | MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
|
|
|
|---|
| BDBM50150754 |
|---|
| n/a |
|---|
| Name | BDBM50150754 |
|---|
| Synonyms: | CHEMBL3775058 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H13ClN4O2 |
|---|
| Mol. Mass. | 304.732 |
|---|
| SMILES | CCn1cnc2n(Cc3ccc(Cl)cc3)c(=O)[nH]c(=O)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
